Perilipin Obesity Gene
How would you like to eat whatever you
want and not gain weight? Researchers at Baylor College of Medicine in
Houston may have discovered a way to make that possible. The scientists
have found a gene that produces a protein that protects fat cells. When
they removed the gene from mice, the rodents stayed lean, even when they
ate more and exercised less.
The protein, called perilipin, coats fat
cells with a protective layer that keeps them from being metabolized by
enzymes. Without perilipin present, fat is immediately metabolized rather
than stored. The researchers bred mice with obesity genes from both parents,
but made sure the new mice didn't have the gene for perilipin production.
These mice consistently burned more calories than normal mice did.
But, researchers say, there are no magic
pills for obesity yet. And many studies that have looked promising in
mice haven't worked as well in humans.
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