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Weight Loss and Endothelial Function Studies
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Other Weight Loss & Endothelial Function Studies

Relatively few comparable weight loss studies exist in the literature to date. Direct measures of the effects of weight loss on endothelial function have been reported by Sasaki et al., who reported improved endothelium-dependent vasodilation with the use of a very low-calorie diet for 2 weeks in obese hypertensive subjects. Circulating markers of endothelial activation have been reported to be improved in obese subjects following 12 weeks of caloric restriction (800 kcal/day), achieving 9 percent weight loss. Circulating levels of inflammatory cytokines were similarly reduced in obese women following a 1-year multidisciplinary weight loss program which achieved at least 10 percent reduction in weight. Although a direct effect of weight loss achieved with d-fenfluramine on ex vivo endothelial function has been reported in aged Sprague-Dawley rats, it is unclear whether this observation reflects an effect of weight loss or a direct effect of the agent used. In sum, the available literature suggests beneficial effects of weight loss on a number of axes related to vascular function. Further studies exploring the salient features of the interventions, including the degree of weight loss achieved and the timing of vascular measures in relation to the restoration of eucaloric diet, will be needed to better understand the interactions of obesity and endothelial function.

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See also:

1. Weight Loss and Endothelial Function in Obesity
2. Affects of Weight Loss on Endothelial Function in Obesity
3. Endothelial Function & Weight Loss Study
4. Responses to Obesity Treatment
5. Other Weight Loss-Endothelial Function Studies
6. Weight Loss Issues

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