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Obesity Study

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Obesity Study - Results
In all, 100 patients (61 percent women) completed the treatment and 67 (71 percent women) completed the 2-y follow-up. The mean (s.d.) weight loss was 12.5 (5.6) percent at the end of group therapy, 6.0 (7.1) percent at 1 y, and 2.6 (7.5) percent at 2 y. At baseline, the mean (s.d.) score for OP-scale was 61.9 (24.6). The mean scores on every RAND-36 scale were markedly lower than in the Finns without chronic conditions. All the scales in HRQL improved markedly during the treatment. During the follow-up, all the scales started to return back towards baseline levels and at 2 y, only obesity-related psychosocial problems and physical functioning were still improved relative to baseline. In categories of weight change at 2 y (>/=10 percent weight loss, 0-9.9 percent weight loss, weight gain), obesity-related psychosocial functioning, physical functioning, and general health showed dose-response improvement with increasing weight loss. A >/=10 percent weight loss at 2 y after treatment was associated with clear improvement in obesity-related psychosocial problems, physical functioning, physical role functioning, bodily pain, general health, mental health, and vitality. A 0-9.9 percent weight loss was associated with improvement in obesity-related psychosocial problems and physical functioning. Weight gain was associated with improvement in obesity-related psychosocial problems and social functioning. The study population was too small to examine possible gender differences.

Obesity Study - Conclusions
Treatment with VLED and behaviour modification produces marked short-term weight loss and clear improvement in all aspects of HRQL. At 2 y after treatment, the average maintained weight loss is modest. However, one-third of patients maintain >/=5 percent weight loss. Improvement in obesity-related psychosocial problems and physical functioning is associated even with &<10 percent of maintained weight loss. Since the pattern of HRQL changes did only partly follow the pattern of weight change as expected, other factors, such as the therapeutic effect of participating in the weight loss program or increase in physical activity, may affect HRQL responses.

Source: Kaukua J, Pekkarinen T, Sane T, Mustajoki P. 1Helsinki University Central Hospital, Peijas Hospital, Department of Internal Medicine, Vantaa, Finland. 2003. International Journal of Obesity

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