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Weight Loss and Syndrome X
Impact of Weight Reduction on Symptoms of Metabolic Syndrome X
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Weight Loss & Syndrome X

Impact of weight loss on the metabolic syndrome X.

Weight Loss Syndrome X Study - Aim
Individuals with the metabolic syndrome X (MS), a clustering of risk factors [triglycerides, glucose, high-density lipoprotein cholesterol, blood pressure (BP), abdominal obesity] defined by the National Cholesterol Education Program (NCEP), are at high risk for coronary heart disease and type 2 diabetes mellitus, and may benefit from aggressive lifestyle modification.

Weight Loss Syndrome X Study - Methods
We reviewed 1 year of consecutive patients' charts to determine the prevalence of the MS in obese individuals enrolled in a medically supervised rapid weight loss program, the correlation of weight change with the components of the MS, and response to diet-induced weight loss.

Weight Loss Syndrome X Study - Results
Out of 185 individuals, 125 (68 percent) met the NCEP definition of the MS. A moderate decrease in weight (6.5 percent) induced by a very low calorie diet (VLCD) resulted in substantial reductions of systolic and diastolic blood pressure (BP), glucose, triglycerides and total cholesterol at 4 weeks. These improvements were sustained at the end of active weight loss (average 16.7 weeks; total weight loss 15.1 percent), with further significant reductions in BP and triglycerides. Weight loss was related to the changes in each criterion of the metabolic syndrome.

Weight Loss Syndrome X Study - Conclusions
The MS is prevalent in two-thirds of obese individuals enrolling in a structured weight loss program. Moderate weight loss with a VLCD markedly improved all aspects of the MS.

Source: Case CC, Jones PH, Nelson K, O'Brian Smith E, Ballantyne CM. Department of Medicine, Baylor College of Medicine, Houston. 2002

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Weight Loss Methods
The science of weight loss and obesity management is constantly evolving, along with research into weight loss drugs, supplements and gastric bypass surgery. At present, however, a balanced diet combined with regular exercise remains the favored weight management strategy of most weight loss experts.

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