Weight Loss Information logo

Sibutramine and Dexfenfluramine Weight Loss Drugs in the Treatment of Obesity
Comparison of Two Obesity Pharmacological Drugs
Weight Loss Information

Questions About Obesity Medications
Appetite Suppressants - Anti-Obesity Drugs - Prescription Obesity Drugs
Development of Diet Pills - Meridia Short-Term Obesity Drug - Xenical Lipase Inhibitors - Xenical Study
Orlistat & Obesity Management - Orlistat Weight Loss Study - Sibutramine FDA Approved Obesity Drug
Sibutramine Study - Obesity Drugs & Diabetes - Risks of Weight Loss Pills - Adipex Obesity Drug
Side Effects of Adipex - Phentermine to Reduce Appetite - Side Effects of Phentermine

A Comparison of Sibutramine and Dexfenfluramine in the Treatment of Obesity

Because long-term weight reduction is often unsuccessful with dietary restriction alone, pharmacological agents have been used to promote weight loss. We have compared the novel (multiple monoamine neurotransmitter reuptake inhibitor) antiobesity drug sibutramine (10 mg once daily) with the extensively studied serotonin-releasing antiobesity agent dexfenfluramine (15 mg twice daily).

226 healthy outpatients (aged 18 to 65 years; body mass index > or =27 kg/m2) were included in a 12-week, randomized, double-blind, parallel group study. The main outcome measures were changes in weight, body mass index, waist and hip circumference and ratio, and safety profiles.

Mean absolute weight loss was 4.5 +/- 0.4 kg in the sibutramine group (n = 112) and 3.2 +/- 0.3 kg in the dexfenfluramine group (n = 112); 4.7 +/- 0.4 kg in the sibutramine group (n = 101); and 3.6 +/- 0.3 kg in the dexfenfluramine group (n = 94). Comparing the two treatments under the conventional null hypothesis of equality as a secondary analysis, weight loss at endpoint in patients receiving sibutramine was significantly greater than that achieved with dexfenfluramine. Both drugs had similar adverse events profiles: 174 patients (77 percent) experienced adverse events; 17 patients withdrew due to adverse events (sibutramine, n = 6; dexfenfluramine, n = 11). Pulse rate

increased significantly in sibutramine-treated patients, but decreased in dexfenfluramine-treated patients.

Sibutramine (10 mg once daily) is at least as effective as dexfenfluramine (15 mg twice daily) in achieving weight loss in patients with obesity.

Source: Hanotin C, Thomas F, Jones SP, Leutenegger E, Drouin P. Medical Direction,Laboratoires Knoll France-BASF Pharma.

Weight Loss Drugs

ACC2 Weight Loss Enzyme - Appetite Suppressant Drugs - Health Risks Appetite Suppressant - Appetite Suppressants Weight Loss - Axokine Diet Drug - C75 Weight Loss Compound - Cholecystokinin Weight Loss - Dexfenfluramine Weight Loss - Didrex Diet Drugs - Depression Diet Drugs - Diet Drugs Usage - Diet Drugs - Diet Pills Eating Exercise - Diet Pills Weight Regain - Weight Loss Drugs Diet Program - Fen Phen - Fenfluramine Weight Loss Drugs - Fluoxetine Weight Loss - GIP Hormone Weight Loss Drug - Ionamin Diet Drugs - KB-141 Weight Loss Compound - Meridia Diet Drugs - Meridia Weight Loss Drug Ban - New Weight Loss Drugsl - Obesity Drugs Guidelines - Obesity Prescription Drug Markets - Obesity Weight Loss Drugs Treatment - Orlistat Lipase Inhibitor - Orlistat Drug Treatment Obesity - Anti-Obesity Drugs Trial Orlistat & Sibutramine - Orlistat Glucose Study - Orlistat Weight Management Advice - Orlistat Unsatisfactory Weight Reduction - Orlistat / Xenical Pills Weight Reduction - Phentermine Appetite Lowering Diet Drugs - Phentermine Weight Loss Drugs - Phenylpropanolamine (PPA) Weight Loss Drug - Prescription Drugs Treatment of Obesity - Sibutramine Binge Eating - Comparison Sibutramine Dexfenfluramine - Sibutramine Health Safety - Sibutramine Energy Weight Management - Sibutramine Abuse - Sibutramine Weight Loss Trial - Sibutramine Weight Loss Drugs - Tenuate Diet Drugs - Topiramate Anti-Obesity Drug - Weight Loss Drug Therapy - Weight Loss Drugs Review - Weight Loss Medication Candidate Evaluation - Weight Loss Medications Guidelines - Weight Loss Anti-Obesity Drugs - Weight Loss Study Orlistat - Weight Loss Pills Overdose - Minimize Health Risks Weight Loss Pills - Weight Loss Pills Do They Work? - Weight Management Drugs Advice - Zenical Weight Loss Drug


Weight Loss Information - Rapid Weight Loss - Diet Program - How to Lose Weight - Best Weight Loss Goals
Weight Loss Advice - Healthy Balanced Diet - Body Fat Percentage - Diets & Weight Loss Programs
Information on Weight Loss Diets - How to Reduce Weight - Weight Management - Weight Loss Surgery Information
Weight Loss Surgery Benefits/Risks - Weight Loss Drugs Advice - Weight Loss Pills / Weight Loss Pills Information
Xenical Weight Loss Drugs - Meridia/Sibutramine Pills - Guide to Diet Pills - Calorie Needs - Weight Loss Supplements
How to Control Weight - Body Mass Index Calculator - Exercise & Fitness to Lose Weight - Weight Health Issues - Obesity
Treatment of Obesity - Advice About Weight Loss - Questions on Weight Loss & Diet - Weight Loss Advice for Women
Weight Loss Advice for Diabetics - Weight Loss Advice for Teenagers - Weight Loss Advice for Adolescents
Diet & Weight Information - Weight Loss Support - Obesity Drug Treatment - Obesity & Gallstones - How to Lower Cholesterol
Dietary Guidelines - Protein, Carbs & Diet - Carbohydrates & Weight Loss - Weight Gain at College
Weight Gain After Quit Smoking - Weight Control in Menopause - Weight Gain in Pregnancy - Weight Control in Pregnancy
Weight Loss Breast-Feeding - Healthy Weight Range - Healthy Weight Loss Diet - Waist Circumference - Weight Cycling
Weight Health Risks - Weight Risks Assessment - Weight Reduction Tips - Weight Loss Guidelines - Weight Loss Products
Weight Loss Tools - Weight Maintenance

Enquiries: Contact Us. See also Terms of Use
© 2003-2018 Weight Loss Information. All Rights Reserved.