Weight Loss Information logo

Sibutramine, Weight Loss and Resting Metabolic Rate (RMR)
Meridia / Sibutramine Does Not Directly Affect Basal Metabolic Rate
Weight Loss Information - Weight Reduction Advice

Questions About Obesity Medications
Appetite Suppressants - Anti-Obesity Drugs - Prescription Obesity Drugs
Development of Diet Pills - Meridia Short-Term Obesity Drug - Xenical Lipase Inhibitors - Xenical Study
Orlistat & Obesity Management - Orlistat Weight Loss Study - Sibutramine FDA Approved Obesity Drug
Sibutramine Study - Obesity Drugs & Diabetes - Risks of Weight Loss Pills - Adipex Obesity Drug
Side Effects of Adipex - Phentermine to Reduce Appetite - Side Effects of Phentermine

Sibutramine Effects on Resting Metabolic Rate (RMR) and Weight Loss

Sibutramine, a monoamine re-uptake inhibitor, has recently been approved by the Food and Drug Administration as a weight loss agent. Sibutramine lowers bodyweight in rodents by reducing energy intake and increasing energy expenditure. Sibutramine facilitates weight loss in human subjects, but it is not clear whether it acts on energy intake, energy expenditure, or both. The present study was a randomized clinical trial designed to assess the effects of sibutramine (at 10 or 30 mg/day) on body weight and resting metabolic rate (RMR). Forty-four overweight women were randomized to 1) placebo; 2) sibutramine at 10 mg/day or, 3) sibutramine at 30 mg/day. All subjects were instructed to consume a 1200 kcal/day diet for 8 weeks while receiving drug or placebo. RMR was assessed by indirect calorimetry at baseline, at 3 hours after the first dose of drug (or placebo), and at the end of the 8-week weight-loss period.

Sibutramine reduced body weight-relative to placebo, but there was no difference between weight loss on the two sibutramine doses. No significant differences in RMR between sibutramine and placebo were seen, either 3-hour post dose or after the 8-week weight-loss period. After the weight loss period, all groups were taken off medication and kept weight stable for another 4 weeks. RMR was measured again and was not different among groups. That there was no change in RMR when sibutramine was stopped further suggests that the drug does not directly affect RMR.

In summary, while sibutramine was shown to be an effective weight-loss agent over 8 weeks, we found no evidence that it increased RMR.

Source: Seagle HM, Bessesen DH, Hill JO. Department of Pediatrics, Center for Human Nutrition, University of Colorado Health Sciences Center, Denver 80262, USA.

Return to Weight Loss Research

Adiposity Weight Obesity - Aspartame Weight Loss - BMI Weight Change - Body Weight Complement - Calcium Body Weight - Weight Loss Carbs Diets - Parents Role Child Obesity - Obesity Weight College Students - Dexfenfluramine Obesity - Diabetes Weight Loss - Diet Behaviors Dieters - Diet Information Internet - Weight Loss Mediterranean - Diet Support Obesity - Dieting College Men - Dieting Readiness Test - High Carb Diets Syndrome X - Drugs Treatment Obesity - Underestimation Energy Intake - Exercise Calories Weight Control - Body Fat Distribution - Food Intake Women - Fat Reduction Breast Cancer - Fat Reduction Thighs - Fatness Phobia Girls - Fenfluramine Dexfenfluramine Weight Loss Drugs - Gallstones Obese Dieters - Hyperthyroidism Weight - Ketogenic Diet Obesity - Leptin Levels in Obese Women Dieters - Long Term Weight Loss - Low Fat Diets Obesity - Maintain Weight Loss - Obesity Immune Function - Nurses Obesity Advice - Obesity African Americans - Obesity Behavioral Program - Obesity Black Females - Obese Black Women - Obesity Counseling - Exercise Obesity - Obesity Health Costs - Obesity Program - Swedish Obesity - Obesity Treatment Food - Olestra Weight Loss - Orlistat Obesity Management - Orlistat - Weight Loss - Behaviors Overweight Adolescents - Pregnancy Weight Obesity - Sibutramine Weight Loss - Stomach Obese Dieters - Sugar Fat Diet - Sugar Weight Loss - Super-Obese Children - Childhood Syndrome X - Visceral Adipose Fat - Visceral Fat Weight Loss - Very Low Calorie Diets - Waist Size Weight Loss - Water Hydration Weight - Weight Adolescents - Calcium Weight - Weight Control Australia - Weight Control Holidays - Weight Control Study - Weight Dieting Women - Weight Loss Electrocardiograms - Weight Effects Pill - Weight Retention Lactation - Weight Loss Adults - AHA Diet Weight Loss - Weight Loss Behaviors Adolescents - Weight Loss Benefits - Weight Loss Cardiovascular Risk - Weight Loss Study Denmark - Weight Loss Diet Brain Function - Weight Loss Diet Oats - Healthy Weight Loss Diets - Weight Loss Eatingn - Weight Loss Elderly - Dietary Fat Energy Restriction Weight Loss - Weight Loss Diet Exercise - Iron Weight Loss - Weight Loss Men - Weight Loss Methods - Intentional Weight Loss Mortality - Weight Loss Sleep Apnea - Weight Loss Practices Adolescents - Weight Loss Rebound - Weight Loss Strategies - Weight Loss Students - Weight Maintenance Diet Methods - Weight Maintenance Diets - Weight Maintenance Program - Obese Girls Boys - Weight Reducing Treatment - Weight Control Navajo - Weight Maintenance Supplementation - Why Lose Weight


Weight Loss Information - Rapid Weight Loss - Diet Program - How to Lose Weight - Best Weight Loss Goals
Weight Loss Advice - Healthy Balanced Diet - Body Fat Percentage - Diets & Weight Loss Programs
Information on Weight Loss Diets - How to Reduce Weight - Weight Management - Weight Loss Surgery Information
Weight Loss Surgery Benefits/Risks - Weight Loss Drugs Advice - Weight Loss Pills / Weight Loss Pills Information
Xenical Weight Loss Drugs - Meridia/Sibutramine Pills - Guide to Diet Pills - Calorie Needs - Weight Loss Supplements
How to Control Weight - Body Mass Index Calculator - Exercise & Fitness to Lose Weight - Weight Health Issues - Obesity
Treatment of Obesity - Advice About Weight Loss - Questions on Weight Loss & Diet - Weight Loss Advice for Women
Weight Loss Advice for Diabetics - Weight Loss Advice for Teenagers - Weight Loss Advice for Adolescents
Diet & Weight Information - Weight Loss Support - Obesity Drug Treatment - Obesity & Gallstones - How to Lower Cholesterol
Dietary Guidelines - Protein, Carbs & Diet - Carbohydrates & Weight Loss - Weight Gain at College
Weight Gain After Quit Smoking - Weight Control in Menopause - Weight Gain in Pregnancy - Weight Control in Pregnancy
Weight Loss Breast-Feeding - Healthy Weight Range - Healthy Weight Loss Diet - Waist Circumference - Weight Cycling
Weight Health Risks - Weight Risks Assessment - Weight Reduction Tips - Weight Loss Guidelines - Weight Loss Products
Weight Loss Tools - Weight Maintenance

Enquiries: Contact Us. See also Terms of Use
© 2003-2018 Weight Loss Information. All Rights Reserved.